Create a folder named 01_Disable_Adobe_Update

In 01_Disable_Adobe_Update create 3 folders:
_Inno
_Intunewin
Install

Download PSAppDeployToolkit and extract

Copy the Toolkit content to Install

Create a Disable_Adobe_Update.ps1 file and save in install\files folder

if((Test-Path -LiteralPath "HKLM:\SOFTWARE\WOW6432Node\Adobe\Adobe ARM\Legacy\Reader\{AC76BA86-7AD7-1033-7B44-AC0F074E4100}") -ne $true) {  New-Item "HKLM:\SOFTWARE\WOW6432Node\Adobe\Adobe ARM\Legacy\Reader\{AC76BA86-7AD7-1033-7B44-AC0F074E4100}" -force -ea SilentlyContinue };
New-ItemProperty -LiteralPath 'HKLM:\SOFTWARE\WOW6432Node\Adobe\Adobe ARM\Legacy\Reader\{AC76BA86-7AD7-1033-7B44-AC0F074E4100}' -Name 'Mode' -Value 0 -PropertyType DWord -Force -ea SilentlyContinue;

if((Test-Path -LiteralPath "HKLM:\SOFTWARE\Policies\Adobe\Acrobat Reader\DC\FeatureLockDown") -ne $true) {  New-Item "HKLM:\SOFTWARE\Policies\Adobe\Acrobat Reader\DC\FeatureLockDown" -force -ea SilentlyContinue };
New-ItemProperty -LiteralPath 'HKLM:\SOFTWARE\Policies\Adobe\Acrobat Reader\DC\FeatureLockDown' -Name 'bUpdater' -Value 0 -PropertyType DWord -Force -ea SilentlyContinue;

Edit in the 01_Disable_Adobe_Update\Install the Deploy-Application.ps1 file

Line: 64 to 76
Add # on line 120
Add # on line 123
Add # on line 160
Add # on line 163
Add below line 140 the script.

$destinationFolder = join-path $envProgramFilesX86 "\Disable_Adobe_Update"
New-Folder -Path $destinationFolder
Copy-File -Path "$dirFiles\*.*" -Destination $destinationFolder\Files
$myParameters = '-ExecutionPolicy Bypass -NoLogo -NonInteractive -NoProfile -File "{0}"' -f "$destinationFolder\Files\Disable_Adobe_Update.ps1"
Execute-Process -Path 'powershell.exe' -Parameters $myParameters -WindowStyle 'hidden'

If you want to delete the shortcut on the desktop add on line 152

Del "$env:PUBLIC\Desktop\Acrobat Reader DC.lnk"

Making Disable_Adobe_Update.exe

Download Inno Setup and install the software

Create in Notepad++ a file Disable_Adobe_Update.iss and save to 01_Disable_Adobe_Update\_Inno

Copy and paste the below code.

; Script generated by the Inno Script Studio Wizard.
; SEE THE DOCUMENTATION FOR DETAILS ON CREATING INNO SETUP SCRIPT FILES!

[Setup]
; NOTE: The value of AppId uniquely identifies this application.
; Do not use the same AppId value in installers for other applications.
; (To generate a new GUID, click Tools | Generate GUID inside the IDE.)
AppId={
AppName=Disable_Adobe_Update
AppVersion=1.0
AppPublisher=knowledgebase.it
AppPublisherURL=https://www.knowledgebase.it
AppSupportURL=https://www.knowledgebase.it
AppUpdatesURL=https://www.knowledgebase.it
DefaultDirName={autopf}\Disable_Adobe_Update
DisableDirPage=yes
DefaultGroupName=Disable_Adobe_Update
DisableProgramGroupPage=yes
OutputDir="C:\Knowledgebase\01_Disable_Adobe_Update\_Intunewin"
OutputBaseFilename=Disable_Adobe_Update
Compression=lzma
SolidCompression=yes

[Files]
Source: "C:\Knowledgebase\01_Disable_Adobe_Update\Install\*"; DestDir: "{app}"; Flags: ignoreversion recursesubdirs createallsubdirs
; NOTE: Don't use "Flags: ignoreversion" on any shared system files

[Run]
Filename: "{app}\Deploy-Application.exe"; Parameters: "Install"; WorkingDir: "{app}"; Flags: waituntilterminated hidewizard runhidden

[UninstallRun]
Filename: "{app}\Deploy-Application.exe"; Parameters: "Uninstall"; WorkingDir: "{app}"; Flags: waituntilterminated hidewizard runhidden

[UninstallDelete]
Type: filesandordirs; Name: "{app}*"

Open the file with Inno Setup Compiler and generate a App id on line 8

Press the play button or F9 on your keyboard.
The .exe is in folder 01_Disable_Adobe_Update_Intunewin \Disable_Adobe_Update.exe

Making Disable_Adobe_Update.intunewin

Create a install.cmd, unistall.cmd and unistall.ps1 file and save in 01_Disable_Adobe_Update_Intunewin folder

Install.cmd

Disable_Adobe_Update.exe /VERYSILENT /SUPPRESSMSGBOXES

Unistall.cmd

@ECHO OFF
SET ThisScriptsDirectory=%~dp0
SET PowerShellScriptPath=%ThisScriptsDirectory%Unistall.ps1
PowerShell -NoProfile -ExecutionPolicy Bypass -Command "& {Start-Process PowerShell -ArgumentList '-NoProfile -ExecutionPolicy Bypass -File ""%PowerShellScriptPath%""' -Verb RunAs}";

Uninstall.ps1

$program = "C:\Program Files (x86)"
& $program\Disable_Adobe_Update\unins000.exe /VERYSILENT /SUPPRESSMSGBOXES

Download IntuneWinAppUtil.exe

Open cmd with admin rights and go to IntuneWinAppUtil.exe

Upload Disable_Adobe_Update.intunewin

https://portal.azure.com/#blade/Microsoft_Intune_Apps/MainMenu/1/selectedMenuItem/Overview

Microsoft Intune > Client apps > Apps
App type: Windows app (Win32)
Name: Disable_Adobe_Update
Description: Disable_Adobe_Update
Pubisher: .
Category: Computer management
Display this as a featured app in the Company Portal: Yes or No
Upload a logo
Wait for complete upload
Install command: Install.cmd
Unistall command: Unistall.cmd
Install behavior: System
Operating system architecture: 64-bit
Minimum operating system: Windows 10 1607
Detection rules>
Rule type: File
Path: C:\Program Files (x86)\
File or folder: Disable_Adobe_Update
Detection method: File or folder exists
Associated with a 32-bit app on 64-bit clients: Yes

Assign a group in Assignments

You can set the Adobe Acrobat Reader DC as a Dependencies
Intune installs the reader first and then the Disable_Adobe_Update.exe